- Gil Gerard as Capt. William "Buck" Rogers
- Erin Gray as Col. Wilma Deering
- Tim O'Connor as Dr. Elias Huer
- Paul Koslo as Commander Reeve
- Gino Conforti as Sylvie
- Mary Woronov as Nola
- Anne Lockhart as Leila Markeson / Jennifer
- Felix Silla as Twiki
- Mel Blanc as Voice of Twiki
- Jessie Lawrence Ferguson as Lieutenant Rekoff
- Cameron Young as Toby Kaplin
- Shawn Michaels as Supervisor
- Dennis Haysbert as Security Guard
- Marsha Mercant as Clerk
- Mitchel Evans as Mime
- William Conrad as Voice of Narrator (uncredited)
- Eric Server as Voice of Dr. Theopolis (uncredited)