- Gil Gerard as Capt. William "Buck" Rogers
- Erin Gray as Col. Wilma Deering
- Tim O'Connor as Dr. Elias Huer
- Anne-Marie Martin as Stella Breed
- John P. Ryan as Kurt Belzack
- Felix Silla as Twiki
- Mel Blanc as Voice of Twiki
- David Darlow as Pinchas
- Bebe Louie as Clare
- Eugenia Wright as Dawn
- Ken Letner as Oto Anad
- William Conrad as Voice of Narrator (uncredited)
- Eric Server as Voice of Dr. Theopolis (uncredited)