*Gil Gerard as Capt. William "Buck" Rogers
- Erin Gray as Col. Wilma Deering
- Thom Christopher as Hawk
- Jay Garner as Admiral Efram Asimov
- Wilfrid Hyde-White as Dr. Goodfellow
- Ramon Bieri as Commissioner Bergstrom
- William Sylvester as Lt. General Preston Myers
- David Hooks as General Arnheim
- Walter Brooke as U.S. President
- John Milford as Air Force General
- Felix Silla as Twiki
- John O'Connell as Major Peterson
- Thomas Bellin as Crawford
- Buck Young as Brigadier General Biles
- Carl Reindel as Air Force Sergeant
- Eric Lawrence as Young Marine
- James Emery as Marine Pilot
- Dean Brooks as Marine Sergeant
- Bill Andes as Colonel Turner (uncredited)
- Mel Blanc as Voice of Twiki (uncredited)
- Jeff David as Voice of Crichton (uncredited)