*Gil Gerard as Capt. William "Buck" Rogers
- Erin Gray as Col. Wilma Deering
- Tim O'Connor as Dr. Elias Huer
- Gary Coleman as Hieronymous Fox
- Patty Maloney as Twiki
- Mel Blanc as Voice of Twiki
- Ana Alicia as Felina Redding (uncredited) (Archive Footage)
- Elizabeth Allen as Roxanne Trent (uncredited) (Archive Footage)
- Michael Ansara as Kane (uncredited) (Archive Footage)
- Victor Argo as Raphael Argus (uncredited) (Archive Footage)
- Kimberly Beck as Alison Michaels (uncredited) (Archive Footage)
- Tara Buckman as Majel (uncredited) (Archive Footage)
- Karen Carlson as Stella Warden (uncredited) (Archive Footage)
- Juanin Clay as Major Marla Landers (uncredited) (Archive Footage)
- William Conrad as Voice of Narrator (uncredited)
- Buster Crabbe as Brigadier Gordon (uncredited) (Archive Footage)
- Jamie Lee Curtis as Jen Burton (uncredited) (Archive Footage)
- Nancy DeCarl as Sherese (uncredited) (Archive Footage)
- Michael DeLano as Malary Pantera (uncredited) (Archive Footage)
- Robert Dowdell as Galen (uncredited) (Archive Footage)
- Ann Dusenberry as Ariela Dyne (uncredited) (Archive Footage)
- Eddie Firestone as Corporal M.K. Schultz (uncredited) (Archive Footage)
- Lester Fletcher as M.D. Toman (uncredited) (Archive Footage)
- Sean Garrison as Flight Controller (uncredited) (Archive Footage)
- Frank Gorshin as Seton Kellogg (uncredited) (Archive Footage)
- Peter Graves as Major Noah Cooper (uncredited) (Archive Footage)
- H.B. Haggerty as Tigerman (uncredited) (Archive Footage)
- Pamela Hensley as Princess Ardala (uncredited) (Archive Footage)
- Walter Hunter as Hugo (uncredited) (Archive Footage)
- Anthony James as Varek (uncredited) (Archive Footage)
- Richard Lynch as Morgan Velosi (uncredited) (Archive Footage)
- Leigh McCloskey as Jalor Davin (uncredited) (Archive Footage)
- Trisha Noble as Sabrina (uncredited) (Archive Footage)
- Jack Palance as Kaleel (uncredited) (Archive Footage)
- Albert Popwell as Koren (uncredited) (Archive Footage)
- John Quade as Jolen Quince (uncredited) (Archive Footage)
- Robert Quarry as Commander Corliss (uncredited) (Archive Footage)
- Jay Robinson as Cassius Thorne (uncredited) (Archive Footage)
- Melody Rogers as Lt. Dia Cyrton (uncredited) (Archive Footage)
- Eric Server as Voice of Dr. Theopolis (uncredited)
- Pamela Susan Shoop as Tangie (uncredited) (Archive Footage)
- Teddi Siddall as Linea (uncredited) (Archive Footage)
- Felix Silla as Twiki (uncredited) (Archive Footage)
- K.T. Stevens as Lt. Twain (uncredited) (Archive Footage)
- Dorothy Stratten as Miss Cosmos (uncredited) (Archive Footage)
- Woody Strode as Sgt. "Big Red" MacMurthy (uncredited) (Archive Footage)
- Dan Sturkie as Eli Twain (uncredited) (Archive Footage)
- Ray Walston as Roderick Zale (uncredited) (Archive Footage)
- Katherine Wiberg as Alicia (uncredited) (Archive Footage)
- Sheila Wills as Major Fields (uncredited) (Archive Footage)
- Joseph Wiseman as Carl Morphus (uncredited) (Archive Footage)