*Gil Gerard as Capt. William "Buck" Rogers
- Erin Gray as Col. Wilma Deering
- Tim O'Connor as Dr. Elias Huer
- Leigh McCloskey as Jalor Davin
- Trisha Noble as Sabrina
- Brett Halsey as Cruise Ship Captain
- Kimberly Beck as Alison Michaels
- Felix Silla as Twiki
- Mel Blanc as Voice of Twiki
- Patty Maloney as Tina
- Timothy O'Hagan as Gurney Langston, Jr.
- Dorothy Stratten as Miss Cosmos
- William Conrad as Voice of Narrator (uncredited)
- Eric Server as Voice of Dr. Theopolis (uncredited)