*Gil Gerard as Capt. William "Buck" Rogers
- Erin Gray as Col. Wilma Deering
- Tim O'Connor as Dr. Elias Huer
- Frank Gorshin as Seton Kellogg
- John Quade as Jolen Quince
- Anthony James as Varek
- James McEachin as Richard Selvan
- Nancy DeCarl as Sherese
- Markie Post as Joella Cameron
- Robert Tessier as Marcos
- James Sloyan as Barnard "Barney" Smith
- Felix Silla as Twiki
- Mel Blanc as Voice of Twiki
- Victor Argo as Raphael Argus
- Whitney Rydbeck as Hartsteen
- Gwenn Mitchell as Ticket Clerk
- Nonice Williams as Katrina
- John Furlong as Cop #1
- Mitch Reta as Technician
- Richard Reed as Rowdy #1
- Seamon Glass as Pirate
- William Conrad as Voice of Narrator (uncredited)
- Eric Server as Voice of Dr. Theopolis (uncredited)