*Gil Gerard as Capt. William "Buck" Rogers
- Erin Gray as Col. Wilma Deering
- Tim O'Connor as Dr. Elias Huer
- Pamela Hensley as Princess Ardala
- Michael Ansara as Kane
- Alfred Ryder as Garedon
- Felix Silla as Twiki
- Mel Blanc as Voice of Twiki
- H.B. Haggerty as Tigerman
- Elaine Nista as Disco Skater #1
- Tracy Miller as Disco Skater #2
- Nancy Morris as Disco Skater #3
- Gary Stang as Disco Skater #4
- William Conrad as Voice of Narrator (uncredited)
- Eric Server as Voice of Dr. Theopolis (uncredited)